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On the other hand, Event scripts are a real bugbear. You have a lot of different issues. First off, there is no central lookup table for events. They can be called from Tile Triggers (most common), NPCs (also fairly common), other events (subroutines), hard coded assembly when using certain items (tent, anyone?), and map entrance events (which, when coded correctly, have to have various branches for any changes you may have made to the map-specific temporary event bits).

Yeah event calls reorganization (NPC data or event triggers) would be a puzzle but not impossible. Some of those calls as you said are directly called from ASM (tent, chest messages, etc...). If in an event editor you edit event X in the middle of the event code, not only you got to reorganize (pack) all events following (and those calls to events) but there are the conditional branching as well in all those events to reorganize. Pretty much a nightmare compared to AI scripts packing / free space optimization. Zone Doctor has implemented an event editor but event in the latest stable release (3.8.4) using it can lead to entire event blocks being corrupted. There are workarounds I've heard but I never bothered using it, I prefer sticking to hex editing.