Unbreakable

I don't really run from battles in general, so maybe that's colouring my perspective a little. That being said, I only had one Soft and one Antidote when I went through there. The enemies there had status effects and nothing else that was all that dangerous, so I didn't feel it was unmanageable.

I still don't think that attacking with Sabin is worth it. I'm assuming that they can use Fireball only on their third turn, like in vanilla (my results while playing Unbreakable were consistent with that). Zerg rushing one using Sabin's physical attacks (assuming only minor damage from the rest of the party, who can't do much here) can't kill one by turn three (at least at my level). However, Pummeling every turn is very likely to kill at least one by their sixth turn. So it's very rare that focusing physical attacks on one, at least in my circumstances, would reduce the chances of a double Fireball at all. The major difference that could be made is if I stole the Claw from Vargas, assuming that can still be stolen. In that case, a Genji Glove setup could be useful, but otherwise there's no source of a second Claw yet and nobody else can use the Genji Glove.

I didn't Steal from Vargas because I would have almost certainly ran out of Tonics.